Formulation, development and characterization of ibuprofen microemulgel for arthritis

Authors

  • M. Hammad Tariq Bhatti Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore. 54000, Pakistan.
  • Sarim Sohail Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore. 54000, Pakistan.
  • M Usama Aslam Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore. 54000, Pakistan.
  • Hana Ather Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore. 54000, Pakistan.
  • Talib Hussain Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore. 54000, Pakistan.
  • Muhammad Kashif Laboratory of Bio-refinery, Guangxi Research Center for Biological Science and Technology, Guangxi Academy of Sciences, Nanning, 530007, China

DOI:

https://doi.org/10.56770/jcp2022623

Keywords:

Microemulsion, Analgesic activity, Zeta potential, Topical formulation, Ibuprofen

Abstract

Objective: Microemulgel is composed of aqueous phase, lipophilic phase, along with surfactant and co-surfactant, a suitable gelling agent is also incorporated. The drug Ibuprofen is non-steroidal anti-inflammatory drug. Its oral administration associated with many GIT, hepatic and renal problems. The main objective of the study was to formulate a stable topical microemulgel of ibuprofen in order to achieve the highest bioavailability with least side effects. Method: Pseudo ternary phase diagram was constructed in order to get the suitable concentrations of lipophilic phase, surfactant and co-surfactant. Phase titration method was used to prepare microemulsion, with surfactant and co-surfactant in a ratio of 2:1 respectively, along with gelling agent to form microemulgel. Formulations were evaluated to check appearance, pH, flowability, particle size, drug content, spreadability, drug release and skin irritation. Results: The globule size of microemulsion was 400 nm and zeta potential was -14 mV showing acceptable stability. Formulated emulgel showed good physical characteristics, suitable pH of 6.4 for skin. The drug content was 98.474%. The stability study showed that the ibuprofen was stable in phosphate buffer pH of 6.8. The carbopol 940 as a gelling agent showed high release rate values. The release rate of the optimized formulation, F1 was 94% and it followed Korsmeyer Peppas model (n=0.467). Conclusion: The prepared formulation was cost-effective because of promising highest bioavailability. The results suggest the potential use of developed microemulgel is mainly for topical delivery of ibuprofen, ensuring the safe use.

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Published

31.12.2022

How to Cite

1.
Bhatti MHT, Sohail S, Aslam MU, Ather H, Hussain T, Muhammad Kashif. Formulation, development and characterization of ibuprofen microemulgel for arthritis. JCP [Internet]. 2022 Dec. 31 [cited 2024 Nov. 23];6(2):57-64. Available from: https://ammanif.com/journal/jcp/index.php/home/article/view/67