Development and evaluation of curcumin-nanoparticle loaded gel for topical application

Abstract

Curcumin, a natural polyphenolic compound found in turmeric, is recognized for its notable antioxidant and antimicrobial properties, making it a promising candidate for therapeutic applications. This research explores the preformulation, characterization, and biological activity of curcumin nanoparticles (CrNp) in detail. The study assessed essential flow properties, such as particle size, shape, angle of repose, bulk and tapped densities, Carr's index, and Hausner ratio, through bulk characterization. Physical properties of curcumin nanoparticles, including particle size and zeta potential, were analyzed, and their encapsulation efficiency was quantified using UV-Vis spectrophotometry. A standard curve was developed for precise measurement of curcumin concentration in DMSO. Additionally, curcumin gel formulations were evaluated for their physical characteristics, including stability, pH, viscosity, and spreadability. Biological activity testing demonstrated the antioxidant capabilities of curcumin and its antimicrobial effectiveness against Staphylococcus aureus and Escherichia coli. An in-vitro release study conducted over 72 hours offered valuable insights into the controlled release profile of curcumin nanoparticles. This comprehensive research underscores the therapeutic potential of curcumin nanoparticles, highlighting their effectiveness in drug delivery systems and antimicrobial treatments. The controlled release behavior observed further enhances the prospects for sustained therapeutic benefits. Overall, this study lays a robust foundation for the development of curcumin-based delivery systems, opening avenues for innovative healthcare solutions.