Formulation and characterization of naproxen gel for the management of pain through topical route

Abstract

The current study focuses on the creation and evaluation of a topical gel that contains the nonsteroidal anti-inflammatory medication (NSAID) naproxen, a pain reliever. Carbopol and propylene glycol were used as gelling agents to guarantee the gel's strength and as penetration enhancers to promote absorption into the skin. Physical attributes like viscosity, pH, and appearance were evaluated. Studies on skin penetration revealed effective absorption, whereas experiments using a flow-through diffusion cell showed a protracted release profile. Stability testing verified that the gel retained its properties in a range of circumstances. The results indicate that this transdermal gel formulation presents a feasible substitute for administering naproxen, improving patient compliance via non-invasive delivery. To confirm the therapeutic effectiveness and safety of this technique, more in vivo research is advised.