Investigating the synergistic effects of resveratrol and metformin on insulin sensitivity and ovulatory function in women with PCOS

Abstract

This study explores the synergistic effects of Resveratrol and Metformin on improving insulin sensitivity and ovulatory function in women with Polycystic Ovary Syndrome (PCOS). As a complex condition, PCOS is characterized by elevated androgen levels, menstrual irregularities, and the presence of ovarian cysts, with significant impacts on reproductive and metabolic health. Addressing this, our randomized, double-blind, placebo-controlled trial involved 100 women diagnosed with PCOS. Participants were divided into two groups, one receiving Metformin alone and the other a combination of Metformin and Resveratrol. Outcomes measured included insulin sensitivity, ovulatory cycles, metabolic and hormonal profiles, and inflammatory markers. Our findings revealed that combination therapy significantly improved ovulatory function, insulin sensitivity, and reduced inflammation compared to Metformin alone. These promising results indicate the potential of combined Resveratrol and Metformin treatment in managing both metabolic and reproductive aspects of PCOS, though further research is necessary to confirm these outcomes and clarify the mechanisms at play.