Synthesis of niosomes of diclofenac sodium and their microscopic evaluation

Authors

  • Muhammad Zaid Government College University Faisalabad
  • Khalil Ahmed Government College University Faisalabad
  • Awais Rasool Government College University Faisalabad
  • Muhammad Adeel Government College University Faisalabad

DOI:

https://doi.org/10.56770/jcp2020411

Keywords:

Niosomes, Diclofenac sodium, Transmission electron microscope, Entrapment efficiency

Abstract

Objective: Incorporation of drugs into non-ionic surfactant vesicles (niosomes) during their manufacture affords a
possible method of achieving controlled release. The aim of this study was to formulate niosomes as carriers for delivery of diclofenac sodium (DCS) to achieve controlled release. Method: Niosomes were prepared by Ether injection method using non-ionic surfactant (Span 80) and cholesterol in ratio of 1:1, the organic solvent (dichloromethane) and phosphate buffer. Results: The prepared niosomes were then evaluated for physical appearance, light microscopy, optical microscopy, transmission electron microscopy and entrapment efficiency.
Conclusion: Diclofenac sodium niosomes were prepared successfully without using charge inducing surfaces and
were confirmed by microscopic evaluation. 

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Published

31.07.2020

How to Cite

1.
Muhammad Zaid, Khalil Ahmed, Awais Rasool, Muhammad Adeel. Synthesis of niosomes of diclofenac sodium and their microscopic evaluation. JCP [Internet]. 2020 Jul. 31 [cited 2024 Nov. 25];4(1):1-4. Available from: https://ammanif.com/journal/jcp/index.php/home/article/view/12