Synthesis of niosomes of diclofenac sodium and their microscopic evaluation

Authors

  • Muhammad Zaid Government College University Faisalabad
  • Khalil Ahmed Government College University Faisalabad
  • Awais Rasool Government College University Faisalabad
  • Muhammad Adeel Government College University Faisalabad

DOI:

https://doi.org/10.56770/jcp2020411

Keywords:

Niosomes, Diclofenac sodium, Transmission electron microscope, Entrapment efficiency

Abstract

Objective: Incorporation of drugs into non-ionic surfactant vesicles (niosomes) during their manufacture affords a
possible method of achieving controlled release. The aim of this study was to formulate niosomes as carriers for delivery of diclofenac sodium (DCS) to achieve controlled release. Method: Niosomes were prepared by Ether injection method using non-ionic surfactant (Span 80) and cholesterol in ratio of 1:1, the organic solvent (dichloromethane) and phosphate buffer. Results: The prepared niosomes were then evaluated for physical appearance, light microscopy, optical microscopy, transmission electron microscopy and entrapment efficiency.
Conclusion: Diclofenac sodium niosomes were prepared successfully without using charge inducing surfaces and
were confirmed by microscopic evaluation. 

Downloads

Published

31.07.2020

How to Cite

1.
Muhammad Zaid, Khalil Ahmed, Awais Rasool, Muhammad Adeel. Synthesis of niosomes of diclofenac sodium and their microscopic evaluation. JCP [Internet]. 2020 Jul. 31 [cited 2024 Nov. 2];4(1):1-4. Available from: https://ammanif.com/journal/jcp/index.php/home/article/view/12