Pharmacological comprehensive overview of methadone from structure to clinical applications and its abuse with toxicity

Abstract

This comprehensive document explores the multifaceted aspects of methadone, a synthetic opioid analgesic and long-acting opioid agonist. It delves into its introduction, structure and classification, synthesis, pharmacokinetics, mechanism of action, dosing, monitoring, clinical uses, and the associated death rate. Methadone's crucial role in pain management and opioid addiction treatment is highlighted, emphasizing its capacity to reduce withdrawal symptoms, cravings, and harm associated with opioid abuse. Challenges, such as overdose risk, tolerance, and regulatory barriers, are discussed. This extensive review underscores the importance of careful management and monitoring when utilizing methadone in various clinical settings.